Is there a general setting guideline for just the best point and shoot pictures?

In a word, no. However, don't be discouraged. You can start with the Auto mode and see how things go. When you hit a picture that doesn't turn out to your liking try another mode -- perhaps a scene mode that fits what you are shooting or even one that doesn't! As your skill improves you will begin to notice that sometimes the color isn't quite right -- that's when you begin to adjust the white balance to match the type of lighting in your situation. It is all a gradual learning process that can be enjoyable if you don't rush it too much. In other words, be sure to take your time and enjoy the subtleties as they arise so that you aren't trying to force the result too much -- more just trying to nudge things in the direction you want them to go. And realize, also, that there are some things beyond these smaller cameras' capabilities no matter how skilled the photographer is. Keep thinking about what you are trying to do while at the same time learning what the camera is trying to tell you it would like to do. The relationship can become more like a team or more like an owner and mule. You get to choose which.